Addressing this challenge will require the convergence of chemical design with precise control of morphology and architecture leading to vehicles with discreet nanostructures and compartmentalization functionality. 14– 20 While drug carriers based on biodegradable poly(lactic acid- co-glycolic acid) (PLGA) nanoparticles developed by Langer and coworkers 21– 23 represent one of the most promising platforms to date, further progress will require a more engineered, multifunctional vehicle. A variety of polymeric platforms have been developed in recent years based on an array of different structures including micelles, 1– 6 dendrimers, 7– 10 hydrogels, 11– 13 and encapsulant particles. ![]() ![]() The design of efficient drug delivery vehicles has been a long standing challenge in polymer and materials science.
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